鸡胸软骨粉和硫酸氨基葡萄糖对大鼠类风湿性关节炎的作用

食品科学 ›› 2008, Vol. 29 ›› Issue (4): 373-377.

鸡胸软骨粉和硫酸氨基葡萄糖对大鼠类风湿性关节炎的作用

陆雪芹, 许时婴

江南大学食品学院；江南大学食品学院；

出版日期:2008-04-15 发布日期:2011-08-24

Effects of Chick Sternal Cartilage and Glucosamine Sulfate on Rheumatoid Arthritis in Sprague-Dawley Rats

LU Xue-Qin, XU Shi-Ying

School of Food Science and Technology, Jiangnan University

Online:2008-04-15 Published:2011-08-24

摘要/Abstract

摘要： 本实验研究了口服鸡胸软骨粉及硫酸氨基葡萄糖对大鼠类风湿性关节炎(RA)病程的作用。以纯II型胶原和完全弗氏佐剂免疫Sprague-Dawley(SD)大鼠,建立大鼠的类风湿性关节炎模型(CIA)。分别采用软骨粉和添加硫酸氨基葡萄糖的软骨粉对大鼠灌胃,通过测定相关指标,观察实验组和对照组大鼠关节炎的发病进程。结果表明,口服鸡胸软骨粉能明显降低CIA大鼠的关节炎指数,缓解关节红肿等症状。同时,实验组大鼠的T淋巴细胞增殖受到抑制,白细胞介素-1(IL-1)、白细胞介素-2(IL-2)、肿瘤坏死因子-α(TNF-α)水平也显著低于阴性对照组。硫酸氨基葡萄糖的添加也缓解了大鼠RA的症状。这为开发鸡胸软骨粉和氨基葡萄糖为原料制备安全有效、无副作用的生物保健品以防治类风湿性关节炎提供了理论基础。

关键词: 鸡胸软骨粉, 类风湿性关节炎, Ⅱ型胶原, 硫酸氨基葡萄糖

Abstract: This experiment studied the influence on rat rheumatoid arthritis (RA) by oral administration of chick sternal cartilage and glucosamine sulfate. The collagen-induced rat rheumatoid arthritis model (CIA) was established in male sprague-dawley (SD) rats with intradermal injection of type II collagen in Freund’s complete adjuvant. CIA rats were treated with oral adminis- tration of chick sternal cartilage and glucosamine sulfate. The development of RA was observed in CIA rats and some relevant characteristics were determined. The results indicated that oral administration of chick sternal cartilage obviously relieved the arthritis symptoms and markly suppressed the lymphocyte proliferation. In addition, the levels of TNF-α, IL-1 and IL-2 in the experimental rats were markedly lowered versus vehicle-treated rats. Hence, our studies demonstrated that chick sternal cartilage and glucosamine sulfate could be applied to prevent and cure the RA as a functional healthy food which are safe and lack of side- effects.

Key words: chick sternal cartilage, rheumatoid arthritis, type II collagen, glucosamine sulfate

陆雪芹, 许时婴. 鸡胸软骨粉和硫酸氨基葡萄糖对大鼠类风湿性关节炎的作用[J]. 食品科学, 2008, 29(4): 373-377.

LU Xue-Qin, XU Shi-Ying. Effects of Chick Sternal Cartilage and Glucosamine Sulfate on Rheumatoid Arthritis in Sprague-Dawley Rats[J]. FOOD SCIENCE, 2008, 29(4): 373-377.

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