食品科学 ›› 2008, Vol. 29 ›› Issue (9): 580-584.

• 营养卫生 • 上一篇    下一篇

共轭亚油酸对动脉粥样硬化大鼠组织脂肪酸组成的影响

 范亚苇, 邓泽元, 李静   

  1. 南昌大学食品科学与技术国家重点实验室南昌大学食品科学与工程系;
  • 出版日期:2008-09-15 发布日期:2011-12-08

Effects of Conjugated Linoleic Acids on Fatty Acid Composition in Atherosclerotic Tissues of Rats

 FAN  Ya-Wei, DENG  Ze-Yuan, LI  Jing   

  1. State Key Laboratory of Food Science and Technology,Department of Food Science and Engineering,Nanchang University,Nanchang 330047,China
  • Online:2008-09-15 Published:2011-12-08

摘要: 本研究通过比较老龄动脉粥样硬化大鼠的肾、肝、心和脑组织脂肪酸的变化,尤其是n-3多不饱和脂肪酸(PUFA)和n-6PUFA的变化,了解共轭亚油酸对大鼠组织脂肪酸组成的影响。本实验用SD动脉粥样硬化老龄大鼠,分别添加不同剂量的CLA(低剂量0.5g/kgbw·d;中剂量1.25g/kgbw·d和高剂量2.5g/kgbw·d)组和对照组进行实验,研究CLA对动脉硬化大鼠的肾、肝、心和脑组织脂肪酸含量和组成的改变。实验结果表明:CLA可以升高肾脏、肝脏和脑组织中n-3PUFA的含量,降低肝脏和心脏中n-6PUFA的含量和n-6/n-3的比值,CLA可能取代了组织中部分n-6PUFA。CLA在组织中的沉积各不相同,心脏中CLA的含量可达15.77%,而脑中CLA的含量仅为0.22%~0.53%之间。这些变化可能预示CLA可以改善动脉硬化大鼠的组织脂肪酸的含量和组成。

关键词: 共轭亚油酸, 老龄大鼠, 组织, 脂肪酸变化

Abstract: The aim of this study was to determine the changes in fatty acid composition, in particular n-3 and n-6 polyunsaturated fatty acids (PUFA) in rat kidney, liver, heart and brain to assess and compare the effects of conjugated linoleic acids(CLA) supplementation. The fatty acid composition in the various tissues of aged atherosclerotic rats was determined and compared. The aged rats were fed with high lipid. They were randomly divided into three groups: low dose (0.5g/kg bw·d), middle dose (1.25 g/kg bw·d) and high dose (2.5 g/kg bw·d) of CLA in diet and control group. The contents of fatty acids in rats tissues were determined. Tissue compositions of total n-3 PUFA increase in brain, liver and kidney of rats fed CLA. The compositions of total n-6 PUFA and n-6/n-3 values decrease in liver and heart tissues of rats fed with CLA. CLA may substitute partial n- 6PUFA in the tissues. Accumulations of CLA are various in the various tissues. The CLA content in heart reaches 15.77 %, but the CLA content in brain is only 0.22%~0.53%.All these indicated that CLA can influence the fatty acid composition and content in tissues on the atherosclerosis rat.

Key words: conjugated linoleic acid, aged rats, tissues, fatty acids