食品科学 ›› 2010, Vol. 31 ›› Issue (17): 392-396.doi: 10.7506/spkx1002-6630-201017088

• 专题论述 • 上一篇    下一篇

金属硫蛋白的研究进展

励建荣1,宣 伟1,李学鹏1,熊春华1,王锡昌2   

  1. 1.浙江省食品安全重点实验室,浙江工商大学食品与生物工程学院 2.上海海洋大学食品学院
  • 收稿日期:2010-01-19 修回日期:2010-06-29 出版日期:2010-09-15 发布日期:2010-12-29
  • 通讯作者: 励建荣 E-mail:lijianrong@zjgsu.edu.cn
  • 基金资助:

    “十一五”国家科技支撑计划重大项目(2008BAD94B09)

Research Progress in Metallothionein

LI Jian-rong1,XUAN Wei1,LI Xue-peng1,XIONG Chun-hua1,WANG Xi-chang2   

  1. 1. Food Safety Key Laboratory of Zhejiang Province, College of Food Science and Biotechnology, Zhejiang Gongshang University,
    Hangzhou 310035, China;2. College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China
  • Received:2010-01-19 Revised:2010-06-29 Online:2010-09-15 Published:2010-12-29
  • Contact: LI Jian-rong E-mail:lijianrong@zjgsu.edu.cn

摘要:

金属硫蛋白(MT)具有调节生物体内微量元素浓度以及对重金属的解毒作用,对激素的调节,细胞代谢的调节,细胞分化和增殖的控制以及参与紫外(UV)诱导反应和清除自由基都有重要作用。本文就金属硫蛋白的性质、生理功能、提取纯化技术、检测技术等研究进展及应用前景进行综述,以期为其开发应用提供参考依据。

关键词: 金属硫蛋白, 理化性质, 生理功能, 重金属

Abstract:

Metallothionein (MT) is a cysteine-rich, highly conserved, low molecular and heavy metal-binding protein, which plays important roles in modulating concentrations of trace elements and detoxification of heavy metals. In addition, MT is also involved in the regulation of hormonal and cell metabolism, the control of cell differentiation and proliferation, UV reaction and the scavenging of free radicals. In this paper, current research progress in the properties, physiological functions, extraction and purification technologies and detection strategies of MT have been reviewed and application prospects have been proposed, which will provide theoretical references and a basis for its future development and applications.

Key words: metallothionein, physico-chemical characteristics, physiological function, heavy metal

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