中心组合设计-响应面分析法优选莽吉柿果皮中总氧杂蒽酮的超声提取工艺

食品科学 ›› 2012, Vol. 33 ›› Issue (22): 17-21.

中心组合设计-响应面分析法优选莽吉柿果皮中总氧杂蒽酮的超声提取工艺

赵岩，蔡恩博，唐强，李哲，张燕娣，张连学*

吉林农业大学中药材学院

收稿日期:2011-09-13 修回日期:2012-10-26 出版日期:2012-11-25 发布日期:2012-11-20
通讯作者: 张连学 E-mail:zlx863@163.com
基金资助:
国家自然科学基金青年基金资助项目;吉林省教育厅“十二五”科学技术研究资助项目

Optimization of Ultrasonic-Assisted Extraction of Total Xanthones from Mangosteen (Garcinia mangostana L.) Pericarp by Central Composite Design Coupled with Response Surface Analysis

Received:2011-09-13 Revised:2012-10-26 Online:2012-11-25 Published:2012-11-20

摘要/Abstract

摘要： 采用中心组合设计方法优化莽吉柿果皮中总氧杂蒽酮的提取工艺，研究乙醇体积分数、超声时间、液固比及其交互作用对总氧杂蒽酮提取率的影响。应用SAS软件和响应面分析相结合的方法，模拟得到回归方程的预测模型和可信度，并通过岭脊分析得到最佳的提取条件为乙醇体积分数90.9%、超声时间73.8min、液固比17.1:1(mL/g)。该条件下提取率为7.73%。

关键词: 莽吉柿, 氧杂蒽酮, 提取工艺, 中心组合设计, 响应面分析

Abstract: A central composite design (CCD) was used to optimize the ultrasonic-assisted extraction of total xanthones from mangosteen pericarp. The effects of ethanol concentration, ultrasonication time and solvent-to-solid ratio as well as their interactions on the extraction rate of total xanthones were investigated. A predictive regression model was developed using the SAS software by response surface analysis and its reliability was validated. The optimal extraction conditions were 90.9% of ethanol concentration, 17.1:1 (mL/g) of solvent-to-solid ratio and 73.8 min of ultrasonication time as determined by ridge analysis, resulting in an average actual yield of total xanthones of 7.73% (n = 3).

Key words: Garcinia mangostana, xanthones, extraction process, central composite design, response surface analysis

赵?岩，蔡恩博，唐?强，李?哲，张燕娣，张连学*. 中心组合设计-响应面分析法优选莽吉柿果皮中总氧杂蒽酮的超声提取工艺[J]. 食品科学, 2012, 33(22): 17-21.

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