食品科学 ›› 2013, Vol. 34 ›› Issue (3): 276-279.

• 营养卫生 • 上一篇    下一篇

绿茶摄入对乳腺癌发病风险影响的Meta分析

任国峰1,杨俊峰2   

  1. 1. 中南大学公共卫生学院
    2. 中南大学
  • 收稿日期:2012-06-16 修回日期:2013-01-14 出版日期:2013-02-15 发布日期:2017-12-29
  • 通讯作者: 任国峰 E-mail:renguofeng@csu.edu.cn

Meta Analysis for Effects of Green Tea Consumption on Risk of Breast Cancer

  • Received:2012-06-16 Revised:2013-01-14 Online:2013-02-15 Published:2017-12-29
  • Contact: REN Guo-Feng E-mail:renguofeng@csu.edu.cn

摘要: 采用Meta分析方法研究茶多酚摄入对妇女乳腺癌发病风险的影响。以“茶多酚”、“茶叶”和“乳腺癌”为主题词及关键词,联合检索1996年1月至2011年12月Medline、Pubmed、Embase、CNKI 数据库和万方数据库发表的相关文献。使用RevMan软件进行效应值的合并和异质性检验,通过漏斗图和Egger回归计算发表偏倚。本次研究共纳入10篇文献,包括12144名乳腺癌病例。通过比较最高摄入组和最低摄入组乳腺癌的发病风险,茶多酚的摄入能够使妇女的乳腺癌发病风险降低18%(合并OR=0.82,95%CI:0.68-0.99;I2=74%,P<0.001),病例对照研究合并后的结果具有统计学意义(合并OR=0.76,95%CI:0.59-0.96;I2=80%,P<0.001),但是队列研究合并后结果为茶多酚对乳腺癌发病风险的影响没有统计学意义(合并OR=0.97,95%CI:0.80-1.18;I2=18%,P=0.30)。因此,摄入茶多酚可能降低妇女乳腺癌的发病风险,但目前研究证据还比较有限。

Abstract: To study the association between green tea consumption and the risk of breast cancer by conducting Meta analysis. Using the key words, tea polyphenol, tea, in combination with breast cancer, databases of the Medline, Pubmed, Embase, CNKI and WANFANG from January 1996 to December 2011 were searched. The analysis of merging effect value and homogeneity were performed by using RevMan software, and the funnel plot and the Egger’s test were adopted to examine the potential publication bias. A total of ten studies met the inclusion criteria and were included, with breast cancer cases number of 12144. Compared the highest consumption group with the lowest consumption group, green tea consumption significantly reduced the breast cancer risk by 18% (pooled OR=0.82, 95%CI: 0.68-0.99; I2=74%, P<0.001), the result also had statistical significance (pooled OR=0.76, 95%CI: 0.59-0.96; I2=80%, P<0.001) when data from case-control studies were pooled, but there was no significance association when cohort studies were pooled (pooled OR=0.97, 95%CI: 0.80-1.18; I2=18%, P=0.30). Therefore, green tea consumption may reduce the risk of breast cancer in women, and the related research evidence is limited to some extent now yet.

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