食品科学 ›› 2007, Vol. 28 ›› Issue (1): 306-308.

• 营养卫生 • 上一篇    下一篇

麦绿素对实验性高脂血症大鼠血脂及MDA、SOD、ET-1、NO的影响

 毛孙忠, 范小芳, 吴小脉, 龚永生, 严哲, 胡良冈   

  1. 温州医学院生物化学教研室; 温州医学院肺心病研究室; 温州医学院肺心病研究室 浙江温州325027; 浙江温州325027;
  • 出版日期:2007-01-15 发布日期:2011-12-31

Effects of Barley Green on Serum Lipid, MDA, SOD, ET-1 and NO of Hyperlipoproteinemia Rats

 MAO  Sun-Zhong, FAN  Xiao-Fang, WU  Xiao-Mai, GONG  Yong-Sheng, YAN  Zhe, HU  Liang-Gang   

  1. 1.Department of Biochemistry, Wenzhou Medical College, Wenzhou 325027, China; 2.Institute of Cor Pulmonale, Wenzhou Medical College, Wenzhou 325027, China
  • Online:2007-01-15 Published:2011-12-31

摘要: 研究麦绿素对食饵性高脂血症大鼠血脂及血浆丙二醛(MDA)、超氧化物歧化酶(SOD)、内皮素1(ET-1)、一氧化氮(NO)的影响。SD大鼠32只,随机均分为四组,即正常八周对照组(8NC)、高脂模型八周组(8HF)、高脂模型四周后再加低剂量麦绿素治疗四周组(BG-L)和高脂模型四周后再加高剂量麦绿素治疗四周组(BG-H)。检测大鼠血脂及血浆MDA、SOD、ET-1、NO的变化。结果表明,麦绿素治疗组同高脂模型八周组比较,血浆总胆固醇(TC)和低密度脂蛋白胆固醇(LDL-C)的含量降低,高密度脂蛋白胆固醇(HDL-C)的含量升高;血浆SOD活性和NO含量明显升高,而MDA和ET-1含量明显降低;提示麦绿素具有降血脂、抗氧化和改善血管内皮功能的作用。

关键词: 高脂血症, 丙二醛, 超氧化物歧化酶, 内皮素, 一氧化氮

Abstract: To observe the effects of barley green on serum lipid and malonyldialdehede (MDA), superoxide dismutase (SOD), endothelin-1(ET-1) and nitric oxide (NO). Thirty two rats were fed high fat diet to result in hyperlipidemia models. Then they were randomly divided into blank group(8NC), model group (8HF), BG-L group (treated by low dose barley green) and BG-H group (treated by high dose barley green). Changes of above laboratory indexes were observed. The level of serum total cholesterol (TC), low-density lipoprotein (LDL), MDA and ET-1 of the groups given medicine was lower than that of the model group, while the level of serum high-density lipoprotein (HDL), SOD and NO of the groups given medicine was higher than that of the model. According to the results, barley green can modulate lipid metabolism, resist lipid peroxidation, improve vascular endothelium and prevent atherosclerosis.

Key words: hyperlipidemia, malonylolialdehede(MDA), superoxide dismutase(SOD), endothelin-1(ET-1), nitric oxide (NO)