食品科学

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类胡萝卜素与癌症风险相关性的研究

翟艳丽1,惠伯棣1,*,蔡 靳2,刘 蕊3,王英明3   

  1. 1.北京联合大学应用文理学院食品科学系,北京 100191;2.河北大学生命科学学院,河北 保定 071002;
    3.新疆红帆生物科技有限公司,新疆 巴音郭楞蒙古自治州 841100
  • 出版日期:2013-07-15 发布日期:2013-06-28
  • 通讯作者: 惠伯棣
  • 基金资助:

    “十一五”国家科技支撑计划项目(2008BAI58B06)

Relationship Between Carotenoids and Cancer Risk

ZHAI Yan-li1,HUI Bo-di1,*,CAI Jin2,LIU Rui3,WANG Ying-ming3   

  1. 1. Department of Food Science, College of Applied Arts and Science, Beijing Union University, Beijing 100191, China;
    2. College of Life Science, Hebei University, Baoding 071002, China;3. Xinjiang Tomato Red Co. Ltd., of Biological Science and
    Technology, Mongolian Autonomous Prefecture of Bayingolin 841100, China
  • Online:2013-07-15 Published:2013-06-28
  • Contact: HUI Bo-di

摘要:

通过综述多种研究的结论试图论证类胡萝卜素和癌症发病率之间的关系。这些研究是在多个水平上展开 的,包括分子、细胞、动物模型、临床以及流行病学水平。得出的结论可概括为:增加富含类胡萝卜素化合物的食 物的摄入量可影响细胞生长失调和癌变中发生的生物和生化进程,从而在某种程度上降低癌症发病的风险。但该结 论并不适用于所有癌症。总之,膳食类胡萝卜素在降低癌症发病风险上将会有很现实的意义。由于流行病学研究数 据的可信度不高以及动物模型与人体的差异等因素,这一结论能在人类征服癌症的漫长过程中起到多大的作用还值 得商榷。

关键词: 类胡萝卜素, 癌症, 膳食, 摄入量, 预防

Abstract:

Through an extensive review of the literature, this article attempts to demonstrate the relationship between
carotenoids and cancer risk. These studies were conducted on the multiple levels such as molecular, cellular, animal,
clinical and epidemiological levels. Conclusions made from these studies can be outlined as: an increased amount of diets
rich in carotenoids was able to have an influence on biological and biochemical processes involved in the development of
cell growth dysregulation and carcinogenesis and reduced the risk of cancer. However, this conclusion was not analogous
between cancers. Anyway, it has a practical significance for dietary carotenoid-induced cancer risk reduction. Due to the
poor reliability of epidemiological study and difference between animal and clinical trails, this conclusion is going to be
questionable on a long way to conquer cancer.

Key words: carotenoid, cancer, dietary pattern, intake, preventive effect

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