食品科学 ›› 2019, Vol. 40 ›› Issue (5): 316-322.doi: 10.7506/spkx1002-6630-20180129-406

• 专题论述 • 上一篇    下一篇

沙门氏菌和单增李斯特菌诱导性耐酸响应机制的研究进展

田牧雨1,张一敏1,董鹏程1,毛衍伟1,梁荣蓉1,朱立贤1,*,罗 欣1,2   

  1. 1.山东农业大学食品科学与工程学院,山东 泰安 271018;2.江苏省肉类生产与加工质量安全控制协同创新中心,江苏 南京 210095
  • 出版日期:2019-03-15 发布日期:2019-04-02
  • 基金资助:
    现代农业产业技术体系建设专项(CRAS-37);山东省牛产业创新团队加工与质量控制岗位项目(SDAIT-09-09);山东省“双一流”奖补资金项目(SYL2017XTTD12)

The Mechanisms of Acid Tolerance Response of Salmonella and Listeria monocytogenes: A Review

TIAN Muyu1, ZHANG Yimin1, DONG Pengcheng1, MAO Yanwei1, LIANG Rongrong1, ZHU Lixian1,*, LUO Xin1,2   

  1. 1. College of Food Science and Engineering, Shandong Agricultural University, Tai’an 271018, China; 2. Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control, Nanjing 210095, China
  • Online:2019-03-15 Published:2019-04-02

摘要: 沙门氏菌和单增李斯特菌被认为是肉制品中最重要的食源性致病菌。它们在弱酸环境下会发生强烈的诱导性耐酸响应,同时诱导产生高毒、耐酸、耐渗透压的高危菌株,是影响消费者健康安全的重大隐患。本文主要从沙门氏菌和单增李斯特菌产生诱导耐酸的发现过程、诱导耐酸响应的危害、产生诱导耐酸的影响因素方面进行概述,进一步从pH值稳态系统、应激蛋白分子的调控及细胞膜组成和流动性调控的角度分析了产生诱导耐酸响应的分子机制。

关键词: 食品安全, 沙门氏菌, 单增李斯特菌, 诱导性耐酸响应, 分子机制

Abstract: Salmonella and Listeria monocytogenes are considered as the major foodborne pathogens in meat products. Both pathogens can develop a strong tolerance response to a weakly acidic environment inducing high toxicity and resistance to acid and osmotic pressure, which poses potential health hazards to consumers. In this article, we mainly review the history of the discovery of the acid tolerance response (ATR) of Salmonella and Listeria monocytogenes, the hazards of ATR and the factors affecting its development. Furthermore, we elucidate the molecular mechanism of ATR based on intracellular pH modulation, stress proteins and cell membrane composition and fluidity.

Key words: food safety, Salmonella, Listeria monocytogenes, acid tolerance response, molecular mechanism

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