• 专题论述 •

### 功能性肽的分离及富集研究进展

1. （1.大连海洋大学食品科学与工程学院，辽宁 大连 116023；2.拱北海关技术中心，广东 珠海 519000）
• 出版日期:2020-01-15 发布日期:2020-01-19
• 基金资助:
“十三五”国家重点研发计划重点专项（2018YFD0901104）；辽宁省博士科研启动基金计划项目（2019-BS-036）； 催化基础国家重点实验室基金课题（N-17-08）；辽宁省教育厅科学研究经费项目（QL201907）

### A Review of the Separation and Enrichment of Functional Peptides

LI Xinwei, LIAO Jia, DONG Xiuyu, ZHOU Xin, YANG Heqi, WU Long, WANG Qiukuan, ZHOU Hui

1. (1. College of Food Science and Engineering, Dalian Ocean University, Dalian 116023, China; 2. Gongbei Customs Technology Center, Zhuhai 519000, China)
• Online:2020-01-15 Published:2020-01-19

Abstract: Functional peptides are widely found in nature. The naturally occurring peptides in the human body are referred to as endogenous peptides, which are closely related to the physiological activities such as growth, metabolism, immunity, and signal transduction of living organisms. Exogenous peptides, with various functions such as anti-tumor, blood pressure lowering, and bone health-promoting effects, can be obtained by protein degradation or synthesized from amino acids. However, endogenous peptides are mostly present in low abundance, and are highly susceptible to high-abundance proteins during enrichment; exogenous peptides are mixed with other components. Therefore, the isolation of exogenous peptides and the enrichment of endogenous peptides are prerequisites for studying their structures and functions. In this paper, the current methods available to separate exogenous peptides and enrich endogenous peptides are reviewed, focusing on their principles, applicable objects, advantages and disadvantages as well as future directions. We hope that this paper will lay a theoretical foundation for the structural analysis and functional development of functional peptides.