黄曲霉毒素B1诱导大鼠肝细胞凋亡率剂量效应模型的构建

摘要/Abstract

摘要： 黄曲霉毒素B1(AFB1)是一种具有遗传毒性和致癌性的霉菌毒素，接触大量的AFB1会导致动物和人类急性肝损伤和死亡。已有研究报道有关AFB1导致肝细胞凋亡的定性研究，但关于AFB1急性暴露于肝脏的定量数据和有关剂量效应模型的研究很少。本研究的目的是通过AFB1诱导大鼠肝细胞凋亡的定量数据，从而构建AFB1诱导大鼠肝细胞凋亡率的剂量效应模型。通过拟合模型获取决定系数和进一步的数学检验表明，伽马模型(R2=0.9964,AIC=37.40,BIC=17.19)优于其他模型。建议选用伽马模型作为AFB1诱导大鼠肝细胞凋亡率最优的剂量效应模型，用于黄曲霉毒素B1风险评估框架中的危害特征描述。

关键词: 黄曲霉毒素B1, 肝细胞凋亡, 风险评估, 剂量效应模型

Abstract: Aflatoxin B1 (AFB1) is a genotoxic and carcinogenic mycotoxin and exposure to a high level of AFB1 can lead to acute liver injury and even death in animals and humans. Qualitative studies on AFB1-induced apoptosis in hepatocytes have been reported, but quantitative data on acute exposure to AFB1 in the liver and studies on dose-response models are scarce. This study aimed to construct a dose-response model of AFB1-induced apoptosis rate in rat hepatocytes by using quantitative data on AFB1-induced apoptosis in rat hepatocytes. The determination coefficients were obtained by fitting the models and further mathematical tests showed that the Gamma model (R2=0.9964, AIC=37.40, BIC=17.19) was superior to other models. The Gamma model was recommended as the optimal dose-response model for the AFB1-induced apoptosis rate in rat hepatocytes for hazard characterization in the framework of AFB1 risk assessment.

Key words: aflatoxin B1, hepatocyte apoptosis, risk assessment, dose-response model

中图分类号:

Q939.99

黄奥迪严佳惠张昭寰刘海泉赵勇欧杰. 黄曲霉毒素B1诱导大鼠肝细胞凋亡率剂量效应模型的构建[J]. 食品科学, 0, (): 0-0.

Ao-Di HUANG Zhaohuan Zhang Yong Zhao. Dose-Response Modeling of Aflatoxin B1-Induced Apoptosis Rate in Rat Hepatocytes[J]. FOOD SCIENCE, 0, (): 0-0.

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