Inhibitory Effect of Combined Administration of Carboxymethyl-chitosan and Adriamycin on Hela Cells

doi:10.7506/spkx1002-6300-200921086

Abstract

Abstract:

Objective: To investigate the effect of combined administration of carboxymethyl chitosan (CM-CTS) and adriamycin (ADR) on proliferation of human cervical carcinoma cell line (Hela) in vitro. Methods: Effects of both drugs on proliferation of tumor cells were evaluated by MTT assay. Results: Alone administration of CM-CTS or ADR revealed an inhibitory effect on proliferation of tumor cells and a synergistic effect on inhibition of tumor cell proliferation was observed under simultaneous administration of both drugs. In addition, sequential administration of ADR followed by CM-CTS had a synergistic effect; in contrast, sequential administration of CM-CTS followed by ADR exhibited an antagonistic effect. Conclusion: Simultaneous administration of CM-CTS and ADR revealed a synergistic effect and sequential administration of CM-CTS and ADR exhibited an unidirectional synergistic effect.

Key words: carboxymethyl-chitosan, adriamycin, MTT assay, Hela, synergistic effect, cell proliferation

CLC Number:

R979.1

YANG Jing-ya，WANG Xiao-ji，ZHANG Jian. Inhibitory Effect of Combined Administration of Carboxymethyl-chitosan and Adriamycin on Hela Cells[J]. FOOD SCIENCE, 2009, 30(21 ): 368-370.

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Inhibitory Effect of Combined Administration of Carboxymethyl-chitosan and Adriamycin on Hela Cells

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