FOOD SCIENCE ›› 2010, Vol. 31 ›› Issue (8): 74-76.doi: 10.7506/spkx1002-6300-201008017

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Response Surface Optimization of Supercritical Carbon Dioxide Extraction of Nomilin from Citrus Seeds

LUO Xi-rong1,FAN Ju-di1,MO Bin-bin2,YANG Jun2,*   

  1. 1. School of Pharmacy, Guiyang Medical University, Guiyang 550004, China ;
    2. Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550002, China
  • Received:2009-06-16 Online:2010-04-15 Published:2010-12-29
  • Contact: YANG Jun2 E-mail:yjsfe@sina.com

Abstract:

Response surface methodology based on a central composite design involving 15 experiments of 3 variables at 3 levels was used to optimize nomilin yield at different levels of key supercritical carbon dioxide extraction parameters such as extraction pressure and temperature and entrainer (95% ethanol) dosage. Results showed that the optimal levels of these parameters for achieving a maximum nomilin yield of (6.27 ± 0.06) mg/g were as follows: extraction pressure 25 MPa, 51 ℃ and entainer dosage 1.5 mL/g.

Key words: citrus seeds, nomilin, supercritical CO2 extraction, response surface methodology

CLC Number: