Abstract:

To investigate the modulation effects of supercritical CO2 extracts of hop, β-acids and hexahydro-β-acids on blood glucose level in diabetic mice, an animal model with alloxan-induced diabetic mellitus was established, and the symptom change of diabetes mellitus was observed before and after a 7-day gastric perfusion therapy with supercritical CO2 extracts of hop, β- acids, hexahydro-β-acids and glybenzoylamide (a control group). The results suggested that the fasting blood glucose level and oral glucose tolerance are reduced after therapy, especially the blood glucose level in mice treated with the high dose of β-acids and supercritical CO2 extracts of hop is similar to that of normal mice (p ＞ 0.05). Moreover, the single factor orthogonal comparison showed that the blood glucose level is significantly different between normal and model groups or between model contrast and model therapy groups (p ＜ 0.01). Among therapy groups, supercritical CO2 extracts of hop, β-acids and hexahydro-β-acids have similar effect to glibenclamide (p＞0.05), and their therapy effects on mouse blood glucose level are positively related to their doses.

Key words: supercritical CO2 extracts of hop, β-acids, hexahydro-β-acids, blood glucose level