Abstract:

In this study, two ways was used to prove and explain the hypoglycemic function of polysaccharides from Lycium ruthenicum Murr. fruit, among which, one way was to preventively administer the normal mice by gavage with the low, middle or high dosages of the polysaccharides for 11 d, and then intraperitoneally inject the prevented mice with alloxan, and another way was to intraperitoneally inject the normal mice with alloxan to establish diabetic models, and then intraperitoneally administer the diabetic mice by gavage with the low, middle or high dosages of the polysaecharides for 21 d. Finally the hepatin in liver, SOD activity and MDA content in serum and liver, and fasting blood glucose level were determined for the control group, diabetic model group, all treatment groups and metformin hydrochloride group. The results showed that the polysaccharides significantly can reduce glucose level in blood and MDA content in blood and liver, and enhance SOD activity in blood and liver and promote conversion of blood glucose into liver glycogen of diabetic mice. In conclusion, the polysaccharides from Lycium ruthenicum Murr. fruit has prevention and therapeutic effects on hyperglycemia, and can effectively enhance the anti-oxidation ability in diabetic mice induced by alloxan.

Key words: Lycium ruthenicum Murr., polysaccharide, mouse, hypoglycemic function, mechanism