Immune Modulation of Polysaccharides from Ganoderma atrum on Immunosuppressed Mice

doi:10.7506/spkx1002-6630-200919070

FOOD SCIENCE ›› 2009, Vol. 30 ›› Issue (19 ): 297-299.doi: 10.7506/spkx1002-6630-200919070

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Immune Modulation of Polysaccharides from Ganoderma atrum on Immunosuppressed Mice

LI Wen-juan，NIE Shao-ping，YU Qiang，LI Jing-en，XIE Ming-yong*

(State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China)

Received:2009-06-10 Online:2009-10-01 Published:2010-12-29
Contact: XIE Ming-yong* E-mail:myxie@ncu.edu.cn

Abstract

Abstract:

Objective: To investigate immune modulation of polysaccharides from Ganoderma atrum on immunosuppressed mice induced by cyclophosphamide. Methods: An immunosuppressed murine model was induced by intraperitoneal injection of cyclophosphamide. Mice were divided into five groups: blank control group, model group, high-dose (100 mg/kg), middledose (50 mg/kg) and low-dose (25 mg/kg) polysaccharide groups. Thymus and spleen index were determined by weight. T and B lymphocyte proliferation were measured by MTT assay. Concentrations of IL-2 and TNF- α in serum were determined by using quantitative sandwich enzyme-linked immunosorbent assay (ELISA) kits. Results: Polysaccharides from Ganoderma atrum could significantly increase thymus and spleen index, T and B lymphocyte proliferation and concentrations of TNF-α and IL-2 in serum. Conclusion: Polysaccharides from Ganoderma atrum have immune-improving functions on immunosuppressed mice induced by cyclophosphamide.

Key words: polysaccharides from Ganoderma atrum, immune, lymphocyte

CLC Number:

Q949.32

LI Wen-juan，NIE Shao-ping，YU Qiang，LI Jing-en，XIE Ming-yong*. Immune Modulation of Polysaccharides from Ganoderma atrum on Immunosuppressed Mice[J]. FOOD SCIENCE, 2009, 30(19 ): 297-299.

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Immune Modulation of Polysaccharides from Ganoderma atrum on Immunosuppressed Mice

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