FOOD SCIENCE ›› 2011, Vol. 32 ›› Issue (7 ): 247-250.doi: 10.7506/spkx1002-6630-201107053

• Bioengineering • Previous Articles     Next Articles

Optimization of Tank Fermentation Conditions for Coenzyme Q10 Production by White Geotrichum candidum

WEI Bao-dong,QI Xin   

  1. College of Food Science, Shenyang Agricultural University, Shenyang 110866, China
  • Received:2010-08-10 Revised:2011-02-25 Online:2011-04-15 Published:2011-03-30

Abstract: For the production of Coenzyme Q10, Geotrichum candidum was intermittent fed-batch cultured in a stirred tank  fermenter, and pH was controlled according to the results of previous studies on shake flask fermentation during the process. The effects of dissolved oxygen, stirring speed, airflow rate, and sugar amount on biomass and coenzyme Q10 production were investigated. The optimal fermentation conditions were determined as follows: dissolved oxygen, 35%-40% and sugar concentration, 2 g/L. Under these optimal conditions, the yield of coenzyme Q10 from batch fermentation was increased from 78.75 to 106.26 mg/L, which exhibited an improvement by 69.8% as compared to shake flask fermentation.

Key words: coenzyme Q10, fermenter, fermentation conditions

CLC Number: