Synthesis and Antibacterial Activity of a New Ni (II) Complex of Prazolone and Alpha-Alanine Shiff Base

doi:10.7506/spkx1002-6630-201123022

Abstract

Abstract: A new ligand containing 1-phenyl-3-methyl-4-benzoyl-5-pyrazolone and α-alanine and its Ni (II) complex was synthesized by refluxing reaction. Their coordination structure and physicochemical properties were characterized using elemental analyzer, IR spectroscopy and UV spectroscopy, their antibacterial activity against Eschetichia coli and Staphylococcus aureus was studied, and their toxicology and teratogenicity of the complex was tested towards KM white mice. The results indicated that the ligand in a keto-form structure could be turned into an enol-form structure after coordination. Both the ligand and its complex had certain antibacterial activity. However, the bacterial activity of the complex was obviously stronger than that of the ligand. Acute toxicity test showed that the complex was non-toxic. Moreover, micronucleus and teratogenicity tests were negative, suggesting that the complex is safe for mammals. Therefore, it is safe and feasible as a new antibacterial agent.

Key words: pyrazolone, alanine, Ni(Ⅱ) complex, antibacterial activity, toxicology test

CLC Number:

TS201.3

LIUXin-wen，ZHANGYan-cui，DONGWen-kui，ZHANGZong-zhou. Synthesis and Antibacterial Activity of a New Ni (II) Complex of Prazolone and Alpha-Alanine Shiff Base[J]. FOOD SCIENCE, 2011, 32(23): 116-120.

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Synthesis and Antibacterial Activity of a New Ni (II) Complex of Prazolone and Alpha-Alanine Shiff Base

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