FOOD SCIENCE ›› 2012, Vol. 33 ›› Issue (5): 323-327.doi: 10.7506/spkx1002-6630-201205067

• Reviews • Previous Articles    

Research Advances in Heterologous Expression of ClassⅡa Bacteriocins from Lactic Acid Bacteria

LIU Guo-rong,,SUN Yong,LI Ping-lan   

  1. 1. Beijing Higher Institution Engineering Research Center of Food Additives and Ingredients, Beijing Key Laboratory of Flavor Chemistry, Beijing Technology and Business University, Beijing 100048, China;2. Beijing Food Research Institute, Beijing 100162, China;3. College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China
  • Online:2012-03-15 Published:2012-03-03

Abstract: Class Ⅱa bacteriocins from lactic acid bacteria, which have a strong antibacterial activity against Listeria monocytogenes, have become a hot topic in the research and development of natural preservatives. However, the bacteriocins are always produced at very low levels under the control of the biosynthesis regulatory system and their extraction is very complex, which makes it very difficult to meet the demands for relevant studies and practical applications. For this reason, the heterogenous expression of classⅡa bacteriocins has been widely studied in recent years. This paper summarizes a comprehensive systematic review of recent studies on the heterogenous expression of the bacteriocins in E. coli, lactic acid bacteria and yeast and points out the current main problems and future research directions.

Key words: classⅡa bacteriocins, Listeria monocytogenes, heterologous expression

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