Effect of (－)-Epigallocatechin Gallate on Cancer Cell Signal Transduction Chain

doi:10.7506/spkx1002-6630-201209065

FOOD SCIENCE ›› 2012, Vol. 33 ›› Issue (9): 319-325.doi: 10.7506/spkx1002-6630-201209065

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Effect of (－)-Epigallocatechin Gallate on Cancer Cell Signal Transduction Chain

JIANG Jie-lin1，WEN Xu-ye1，HU Ya-qiong1，LUO Li-yong1,2,3，XIAO Hai-jun4，ZENG Liang1,2,3,*

(1. College of Food Science, Southwest University, Chongqing 400715, China； 2. Chongqing Key Laboratory of Agricultural Products Processing, Chongqing 400715, China； 3. Tea Research Institute, Southwest University, Chongqing 400715, China；4. Technology Center Laboratory of Menghai Tea Industry Limited Liability Company, TAETEA Group, Xishuangbanna 666200, China)

Online:2012-05-15 Published:2012-05-07

Abstract

Abstract: EGCG is not only an important active component in tea extract, but also one of the most potential chemopreventive agents. EGCG has obvious impacts on a variety of signaling pathways in cancer cells, thus leading to the inhibition of cancer cell proliferation, accelerating apoptosis and suppressing cell migration and invasion. Current research is focused on MAPK, PI3K-Akt, NF-κB and other signaling pathways. In this paper, the effect of EGCG on different signal transduction chains is summarized.

Key words: EGCG, signal transduction, MAPK, PI3K-Akt

CLC Number:

JIANGJie-lin，WENXu-ye，HUYa-qiong，LUOLi-yong，XIAOHai-jun，ZENGLiang,,. Effect of (－)-Epigallocatechin Gallate on Cancer Cell Signal Transduction Chain[J]. FOOD SCIENCE, 2012, 33(9): 319-325.

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Effect of (－)-Epigallocatechin Gallate on Cancer Cell Signal Transduction Chain

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