Gold Nanoparticles Modified Electrode for Electrochemical Determination of Salbutamol

doi:10.7506/spkx1002-6630-201224057

Abstract

Abstract: A gold nanoparticle-modified carbon paste electrode (CPE) was prepared and used to determine salbutamol (Sal). The electrochemical behavior of Sal on the modified electrode was investigated by cyclic voltammetric and square wave voltammetry. An irreversible oxidation peak was observed with the modified CPE at 0.60 V (vs. SCE) and the electrochemical response of Sal was significantly enhanced compared with that obtained with a bare CPE. There was a good linear relationship between the anodic peak current and the concentration of Sal over the range of 0.471–64.2 μmol/L and a limit of detection of 0.15 μmol/L (RSN = 3) was achieved. The relative standard derivation was 1.7% for 11 repeated determination of 40.7 μmol/L Sal. This method can be used for the determination of Sal in blood and urine with good results.

Key words: electrochemistry, gold nanoparticles, chemically modified electrode, salbutamol

CLC Number:

O657.1

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