Abstract:

Objective: To explore the effect of 1-palmitoyl-2-oleoyl-3-O-α-D-glucopyranosylglycerol (POGDG) as a
glucosyldiacylglycerol (GDG) isolated from Sargassum fulvellum on plasma triglycerol (TG), lipoprotein and blood glucose
(BG, GLU) levels in arteriosclerosis (AS) mice. Methods: Mice were divided into control group, high-dose (90 mg/(kg·d)) treatment
group, middle-dose (60 mg/(kg·d)) treatment group, low-dose (30 mg/(kg·d)) treatment group, and rutin group (100 mg/(kg·d)).
The mice from control group were administered with saline, and those from treatment groups were administered with POGDG
and quercetin-3-rutinoside by intragastric administration, respectively. After administration for 35 days, the blood was collected
and the levels of triglycerol, lipoprotein, total cholesterol and blood glucose in plasma were determined. Results: Compared
with the control group, the levels of TG and GLU in POGDG treatment groups revealed a significant reduction, and HDL-C
revealed an obvious increase. Meanwhile, the levels of TC, HDL-C and GLU in POGDG treatment groups were similar to those
in rutin group. Conclusion: POGDG can enhance the fibrinolysis and degradation of AS in mice.

Key words: glucosyldiacylglycerol, arteriosclerosis, serum lipid, total cholesterol, blood glucose