FOOD SCIENCE ›› 2014, Vol. 35 ›› Issue (1): 209-213.doi: 10.7506/spkx1002-6630-201401041

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Hypoglycemic Effect of Lily Polysaccharides in Type Ⅰ Diabetic Rats

XIAO Xia, WU Xiong, HE Chun-lian*   

  1. Medical College, Hunan Normal University, Changsha 410006, China
  • Received:2013-01-19 Revised:2013-12-27 Online:2014-01-15 Published:2014-01-22
  • Contact: HE Chun-Lian E-mail:chunlianhe68@163.com

Abstract:

Objective: To explore the hypoglycemic effect of lily polysaccharides in type Ⅰ diabetic rats. Methods: Lily
polysaccharide was extracted from fresh lily bulbs and purified through ion-exchange chromatography on a DEAE52
cellulose column. An alkaline-soluble fraction was obtained from the eluates from the DEAE52 cellulose column and proved
to be a single component by gel filtration chromatography. The purified polysaccharide was used to treat rat models of type
Ⅰ diabetes induced by streptozotocin. The changes in body weight, fasting blood glucose (FBG), insulin (INS), hexokinase
(HK), succinic dehydrogenase (SDH), total superoxide dismutase (T-SOD) and malondialdehyde (MDA) were determined
in diabetic rats before and after the treatment. Results: The lily polysaccharide could significantly slow down the negative
growth of body weights in diabetic rats, reduce the contents of FBG (P < 0.01) and MDA (P < 0.05), and significantly
increase INS, HK, SDH and T-SOD (P < 0.01). Conclusion: Lily polysaccharide exerts hypoglycemic effect in type Ⅰ
diabetic rats through enhancing the activities of antioxidant enzymes, improving antioxidant function, inhibiting oxygen free
radical damage to pancreatic β cells and increasing insulin secretion.

Key words: lily polysaccharide, type I diabetic rats, insulin (INS), superoxide dismutase (SOD)

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