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Preventive Effect of Resistant Starch on Gastric Lesions in Rats

QIAN Yu, ZHAO Xin   

  1. Department of Biological and Chemical Engineering, Chongqing University of Education, Chongqing 400067, China
  • Online:2014-06-15 Published:2014-07-03

Abstract:

Rats were fed on a basal diet supplemented different levels of high-amylose corn starch (Hylon Ⅶ) to explore the
effect of resistant starch on hydrochloric acid/ethanol-induced gastric lesions in rats using ELISA and reverse transcription-
PCR (RT-PCR). The results showed that 10% RS2, 15% RS2 and 20% RS2 groups could reduce serum IL-6 and TNF-α
levels and gastric lesion area, and significantly increase the inhibition rate of gastric lesions when compared with the stomach
injury control group. In addition, these three concentrations of RS2 could decrease the secretion of gastric juice, and increase
gastric pH. These results suggest that RS2 at the three concentration levels has a significant preventive effect on hydrochloric
acid/ethanol-induced gastric lesions in rats and 20% RS2 is the most effective level.

Key words: resistant starch, gastric lesions, hydrochloric acid/ethanol-induced, serum IL-6, serum TNF-α