Abstract:

Objective: The effects of xylobiose on blood fat, blood sugar and fat accumulation of diet-induced obese rats were
studied. Methods: Totally 62 male SD rats were chosen in this study, in which 10 rats in the control group received normal
feed, and 44 rats in the model group were randomized into low-dose xylobiose group (200 mg/(kg·d)), high-dose xylobiose
group (400 mg/(kg·d)) and positive control group (sibutramine hydrochloride with 4 mg/(kg·d)) and model control group
with 11 animals each, all of which received high sugar and high fat diet for 80 continuous days. Serum and body indexes
were tested on the 20th, 40th, 60th and 80th day. Results: The body weights of rats in the administration groups were decreased
compared with the model group (P ＜ 0.01); on the 60th and 80th days, blood sugar values were insignificantly different
from those of the control group, but lower than those of the model control group significantly (P ＜0.01). TG and LDL-C
levels decreased in all the administration groups compared with the model control group (P ＜0.01), but without effects
on LC or HDL-C. The Lee’s indexes of sacrificed rats in the administration groups were significantly different compared
with the model group after feeding for 80 days, as well as the ratio of wet weight of fat pad to body fat which had doseeffect
relationship. Conclusion: Xylobiose can reduce the blood sugar and blood fat and inhibit the fat accumulation of dietinduced
obese rats.

Key words: xylobiose, xylooligosaccharides, obesity model, anti-obesity