Immunoregulatory Activity of Lactobacillus acidophilus Peptidoglycan in Mouse Intestinal Mucosa

doi:10.7506/spkx1002-6630-201513038

Abstract

Abstract:

As an important immune system, mucosal immune system is the first line to protect the mucous membranes
against colonization and invasion by potentially dangerous microbes that may be encountered. In this study, the
immunoregulatory activity of Lactobacillus acidophilus peptidoglycan (PG) was investigated on pathogenic Escherichia coli
(E. coli)-induced mouse model. Compared with PG, the oxidative modification of PG had a significant effect on the secretion
of sIgA, reduced the expression of interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) in the intestinal mucosa. PG
derived from Lactobacillus acidophilus had the capability of enhancing immune regulation of intestinal mucosa.

Key words: Lactobacillus acidophilus, peptidoglycan, intestinal mucosa, immunoregulatory activity

CLC Number:

TS201.3

WU Zhen1, PAN Daodong1,2,*, GUO Yuxing1, ZENG Xiaoqun2, SUN Yangying2. Immunoregulatory Activity of Lactobacillus acidophilus Peptidoglycan in Mouse Intestinal Mucosa[J]. FOOD SCIENCE, doi: 10.7506/spkx1002-6630-201513038.

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Immunoregulatory Activity of Lactobacillus acidophilus Peptidoglycan in Mouse Intestinal Mucosa

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