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Rapid Determination of 13 Synthetic Saturated Lactones Added as Flavors in Beverage by QuEChERS Method Coupled with Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry

WANG Yujian1, JI Shaofan1, CHEN Wenhui1, HUANG Huiling1, DONG Cunzhu2,*   

  1. 1. Inspection and Quarantine Technology Center, Hainan Entry-Exit Inspection and Quarantine Bureau, Haikou 570311, China;
    2. College of Environment and Plant Protection, Hainan University, Haikou 570228, China
  • Online:2016-06-25 Published:2016-06-29
  • Contact: DONG Cunzhu

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Abstract:

method for determining 13 synthetic saturated lactones added as flavors in beverage by ultra performance
liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was established. The target compounds were
extracted with acetonitrile and determined by quick easy cheap effective rugged and safe (QuEChERS) pretreatment
coupled with UPLC-MS/MS (under MRM mode) with an external standard method. The limits of detection (LODs) were
0.025 μg/mL for the instrument and 0.10 mg/kg for the method, respectively. The limit of quantitation (LOQ) was
0.40 mg/kg for the method. The average recoveries of 13 lactones were between 88.5% and 103% at spiked levels of 0.10,
0.20 and 0.40 mg/kg with relative standard derivation (RSDs) of 3.8%–11% (n = 10). The method was reliable and allowed
simultaneous quantitative determination of saturated lactones in beverage.

Key words: saturated lactones, beverage, QuEChERS, ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)

CLC Number: