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Dietary Polyphenols Modulate Lipid Metabolism by Regulating Farnesoid X Receptor: A Review

XIAO Juan1,2, ZHANG Ruifen2, WEN Yejie2, HUANG Fei2, ZHANG Mingwei2, SUN Yuanming1,*   

  1. 1. College of Food Science, South China Agricultural University, Guangzhou 510642, China; 2. Key Laboratory of Functional Foods, Ministry of Agriculture, Guangdong Key Laboratory of Agricultural Products Processing, Sericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510610, China
  • Online:2017-04-15 Published:2017-04-24

Abstract: Hyperlipidemia is an underlying cause of many chronic diseases, and the cardiovascular diseases and other chronic diseases partially caused by hyperlipidemia has become a worldwide public health problem. Farnesoid X receptor (FXR) plays a key role in the regulation of cholesterol and triglycerides metabolism. FXR might be a pharmacological target for the treatment of hyperlipidemia and related diseases. Dietary polyphenols can exert hypolipidemic activity by regulating FXR and its targeted genes. This paper reviews the advances in understanding the mechanism of action of FXR in modulating lipid metabolism and the possible effect of dietary polyphenols in such a bioprocess.

Key words: polyphenols, lipid metabolism, farnesoid X receptor (FXR)

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