Abstract: Citrus flavonoids, with various biological activities such as antioxidant, anti-inflammatory, dyslipidemiaregulating, anticancer and neuroprotective effects, are one of the most important sources of dietary flavonoids. However, the oral bioavailability of most citrus flavonoids is a bit low. In this review, recent advances in the mechanism of the versatile bioactivities of citrus flavonoids and in the development of technologies for enhancing citrus flavonoid bioavailability such as cyclodextrin inclusion, enzymatic treatment, and the use of liposome delivery system and emulsion delivery system are systematically summarized. Furthermore, future research directions and potential applications are presented. We hope that this review will provide useful information for the development of citrus flavonoids-based nutraceuticals and auxiliary drugs.

Key words: citrus flavonoids, biological activities, mechanism, bioavailability