Abstract: The hypolipidemic activity of the seed oil and procyanidins of Rosa davurica Pall. was investigated by animal tests. Kunming male mice fed a high fat diet were used as a hyperlipidemic animal model. After oral administration for 5 weeks, serum and liver homogenate were collected for the measurement of parameters of interest. Compared with the hyperlipidemic model group, both drugs had no significant effect on body weight and visceral organ indexes in mice. The proanthocyanidins at middle (100 mg/kg) and high doses (200 mg/kg) could significantly reduce serum LDL-C, TC and TG (P < 0.05), significantly improve liver superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) levels (P < 0.05), and significantly decrease liver MDA level. The oil at low dose (80 mg/kg) could evidently reduce serum TG levels in hyperlipidemic mice (P < 0.05) and significantly increase in liver CAT activity (P < 0.05). Therefore, the seed oil at low dose and the procyanidins at middle and high doses play a role in reducing blood lipids in hyperlipidemic mice.

Key words: Rosa davurica Pall. seed oil, procyanidins, lipid-lowering activity