FOOD SCIENCE ›› 2020, Vol. 41 ›› Issue (7): 306-314.doi: 10.7506/spkx1002-6630-20190408-072

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Recent Advances in Applying Lactic Acid Bacteria for Alleviating Alcoholic Liver Disease

LI Huizhen, SHI Jialu, ZHAN Meng, GUAN Jiaqi, YAN Fenfen, HUO Guicheng   

  1. (Key Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural University, Harbin 150030, China)
  • Online:2020-04-15 Published:2020-04-20

Abstract: Although various drugs have already been used in a large number of animal and clinical studies to prevent or treat alcoholic liver disease, so far the drug treatments still may cause some side effects at various stages of alcoholic liver disease. As it is increasingly recognized that the gut microbiota plays an important role in the development and progression of various diseases, the potential role of lactic acid bacteria in treating alcoholic liver disease is receiving growing interest from researchers. Recent worldwide studies have found that lactic acid bacteria can alleviate alcoholic liver disease in many aspects. This article reviews the absorption and metabolism of alcohol in the body and the pathogenesis of alcoholic liver disease, as well as the mechanism by which lactic acid bacteria can alleviate alcoholic liver disease, namely by regulating the intestinal microbiota, improving intestinal barrier function, reducing liver oxidative stress, regulating liver inflammation and inhibiting liver fat accumulation, so as to provide a theoretical basis for the prevention and treatment of alcoholic liver disease by lactic acid bacteria.

Key words: lactic acid bacteria, alcoholic liver disease, mechanism, absorption, metabolism

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