Abstract: Recently, naturally bioactive components have been increasingly favored by consumers due to their health benefits. In modern society, selection of naturally bioactive components especially food-borne bioactive ingredients, which are beneficial for one or more human body functions and closely related to many physiological functions essential to maintain life, for nutritional health care and health management has become a trend. Cardiac injury is a common toxic-side effect of the antitumor agent doxorubicin (DOX), and the underlying mechanism is complicated, limiting the clinical application of DOX. Fortunately, resveratrol, widely present in plants, such as peanut, grape, knotweed and mulberry, has potent cardioprotective effects. Moreover, resveratrol can prevent DOX from exerting its cardiotoxicity when they are applied together. Herein, recent advances in the cardioprotective effect of resveratrol against DOX-induced cardiotoxicity are reviewed, which will provide reference for the prevention and attenuation of DOX-induced cardiotoxicity.

Key words: doxorubicin; cardiotoxicity; cardioprotection; resveratrol