FOOD SCIENCE ›› 2021, Vol. 42 ›› Issue (20): 238-245.doi: 10.7506/spkx1002-6630-20200703-039

• Safety Detection • Previous Articles     Next Articles

Migration and Prediction of Furazolidone Residue in Turbot (Scophthalmus Maximus) Exposed to Low-Dose Furazolidone

XING Lihong, SUN Weihong, LI Yiguang, PENG Jixing, LI Zhaoxin, ZHAI Yuxiu   

  1. (1. Key Laboratory of Testing and Evaluation for Aquatic Product Safety and Quality, Ministry of Agriculture and Rural Affairs, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China; 2. Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao 266237, China; 3. Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian 116034, China)
  • Online:2021-10-25 Published:2021-11-12

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Abstract: In order to evaluate the risk of furazolidone residue in turbot (Scophthalmus maximus) under low-dose exposure to furazolidone in the aquaculture environment and to predict the distribution of furazolidone residue in aquatic products scientifically, the fish were fed on a diet supplemented with furazolidone at concentrations of 0.5, 1.5 and 5.0 mg/kg for 30 days at (16 ± 2) ℃ in this study. During this period, the residue of the furazolidone metabolite, 3-amino-2-oxazolidinone (AOZ) in turbot was determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The relationship between the concentration of furazolidone added to the feed and AOZ residue, steady-state enrichment time, tissue distribution characteristics and bioaccumulation factor (BCF) were determined, and a discriminant model was established to predict the concentration of furazolidone in the feed. The results showed that there was a positive correlation between AOZ residue in turbot and furazolidone concentration in the feed. At 0.5, 1.5 and 5.0 mg/kg furazolidone concentrations, the time required for AOZ to reach steady-state enrichment in muscle and skin was 15, 15 and 25 days, respectively. The distribution of AOZ in different tissues was similar, and the level of AOZ residue followed the decreasing order: liver > kidney > spleen > gill > skin > muscle. The BCF of furazolidone in turbot when added at low concentration to the feed was higher than at high concentration. When the concentration of furazolidone in the feed was greater than or equal to 0.68 mg/kg, the AOZ residue in the muscle of turbot was greater than or equal to 1.0 μg/kg after continuous feeding for 30 days. When the concentration of furazolidone in the feed was greater than or equal to 0.46 mg/kg, the same result was observed for the skin. The trace residue of furazolidone in turbot may be related to the polluted farming environment. Through model prediction and scientific monitoring, the risk of pollution caused by the farming process can be reduced to guarantee the safety of aquatic products for consumption.

Key words: furazolidone; 3-amino-2-oxazolidinone; turbot; feed; migration

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