Rapid Screening and Confirmation of 56 Illegally Added Drugs in Herbal Tea by Ultra-high Performance Liquid Chromatography-High Resolution Mass Spectrometry

doi:10.7506/spkx1002-6630-20210204-080

Abstract

Abstract: A rapid screening method for 56 illegally added drugs in herbal tea was developed by ultra-high performance liquid chromatography-high resolution mass spectrometry (UPLC-HRMS). The samples were extracted with methanol and separated on an Accucore RP-MS column (100 mm × 2.1 mm, 2.6 μm) by gradient elution. A full mass scan/data dependent MS2 (Full MS/dd MS2) mode was used to collect data for rapid screening and confirmation. The correlation coefficients (R2) of the calibration curves of the analytes were all greater than 0.99 in the concentration range of 2–100 μg/L. The average recoveries ranged from 90.4% to 105.0% at three different spiked levels with relative standard deviations (RSDs) not more than 6.0%, the limits of detection were between 0.5 and 2.5 μg/L, and the limits of quantification were between 1.5 μg/L to 8.0 μg/L. This method was rapid, accurate and sensitive, and it was suitable for simultaneous screening and quantitation. It can be used for rapid screening and confirmation of illegal additives in herbal tea.

Key words: ultra-high performance liquid chromatography; high resolution mass spectrometry; illegal additives; rapid screening; herbal tea

CLC Number:

O657.63

LIU Guilian, CHEN Ru, LUO Xiaobao, CHEN Junzheng, ZHU Jiayi. Rapid Screening and Confirmation of 56 Illegally Added Drugs in Herbal Tea by Ultra-high Performance Liquid Chromatography-High Resolution Mass Spectrometry[J]. FOOD SCIENCE, 2022, 43(10): 336-341.

[1]	Gui-Lian LIU. Rapid Screening and Confirmation of 56 Illegally Added Drugs in Herbal tea byUltra High Performance Liquid Chromatography-High Resolution Mass Spectrometry [J]. FOOD SCIENCE, 0, (): 0-0.
[2]	Ni ZHANG. Study on the pollution difference of harmful esters in infant formula powder and its ingredient oils [J]. FOOD SCIENCE, 0, (): 0-0.
[3]	rongfeng chen fengming chen Guo-guang ZHANG. Determination of 8 Nicotine Compounds in Edible Fungi by QuEChERS-High Performance Liquid Chromatography-Mass Spectrometry [J]. , 0, (): 0-0.
[4]	Song-Min SONGMIN. Determination of 19 Kinds of Sex Hormones in Health Foods by Ultra Performance Convergence Chromatography-Tandem Mass Spectrometry with Pass-Through Solid Phase Extraction [J]. FOOD SCIENCE, 0, (): 0-0.
[5]	FU Lijun, LIU Li, ZHANG Xiumin, MA Yongzheng, SUN Yong, YUE Tian, XU Mingfang. Quantitative Detection of Ergosterol in Edible Fungi by Nuclear Magnetic Resonance Spectroscopy [J]. FOOD SCIENCE, 2021, 42(20): 135-144.
[6]	RUISHENG ZHENG Zong pingZheng. Evaluation of heavy metal pollution status and edible safety of the nine species of offshore fishes [J]. FOOD SCIENCE, 0, (): 0-0.
[7]	. Determination of 30 Food-borne Stimulant Drug Residues in Pork and Beef Samples Using Ultra Performance Liquid Chromatography Coupled with Quadrupole - Time of Flight Mass Spectrometry [J]. , 0, (): 0-0.
[8]	ZHANG Hao, JIANG Xiaohong, HUO Zongli. Determination of Chlorate and Perchlorate in Infant Formula Powder by Ion Chromatography Coupled with Tandem Mass Spectrometry Based on Captiva EMR-Lipid Clean-up [J]. FOOD SCIENCE, 2021, 42(12): 315-321.
[9]	Yan Zhang KANG Wen-yi. Determination of Five Antiviral Drugs Residues in Chicken and Egg Using Liquid Chromatography -Tandem Mass Spectrometry Based On-line Solid Phase Extraction Purification [J]. , 0, (): 0-0.
[10]	MA Junmei, HE Liangna, SUN Lei, WANG Dong, ZHANG Leilei, ZHANG Yan, KANG Wenyi. Determination of Five Antiviral Drug Residues in Chicken Meat and Eggs Using On-line Solid Phase Extraction Coupled to Liquid Chromatography-Tandem Mass Spectrometry [J]. FOOD SCIENCE, 2021, 42(10): 305-310.
[11]	Yu-Chao FENG Liyuan Zhang. Analysis of Rice Metabolites in Different Regions by GC-MS [J]. , 0, (): 0-0.
[12]	ZHANG Shu, WANG Changyuan, FENG Yuchao, SHENG Yanan, FU Tianxin, ZHANG Yiwei, JIANG Yingjun, YU Miao, ZHANG Liyuan. Analysis of Metabolites in Rice Produced in Different Regions by GC-MS-based Metabonomics [J]. FOOD SCIENCE, 2021, 42(8): 206-213.
[13]	ZHANG Ping, LIU Hongwei, HUANG Jianhua, CHEN Lin. Determination of Major and Trace Metal Elements in Beer by Microwave Plasma-Atomic Emission Spectroscopy [J]. FOOD SCIENCE, 2021, 42(8): 243-247.
[14]	. Determination of Major and Trace Metal Elements in Beer by Microwave Plasma Atomic Emission Spectroscopy [J]. FOOD SCIENCE, 0, (): 0-0.
[15]	LIU Hanlu, ZHANG Jiukai, HAN Jianxun, SUN Ruixue, CHEN Ying, LIU Bing. Analysis of Differential Composition between Not from Concentrate and from Concentrate Orange Juices Using UPLC-QTOF-MS-Based Metabolomics [J]. FOOD SCIENCE, 2021, 42(6): 229-237.

Rapid Screening and Confirmation of 56 Illegally Added Drugs in Herbal Tea by Ultra-high Performance Liquid Chromatography-High Resolution Mass Spectrometry

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments