Functional Significance and Structure-Activity Relationship of Food-Derived Protein Tyrosine Phosphatase 1B Inhibitors

doi:10.7506/spkx1002-6630-20220922-220

Abstract

Abstract: Protein tyrosine phosphatase 1B (PTP1B), a potential target for the treatment of type 2 diabetes and obesity, plays a key negative regulatory role in the insulin and leptin signaling pathways. Natural products, with structural diversity, can affect different targets and pathways to exert their unique preventive and therapeutic effects on diabetes or its complications. Various food-derived natural products have been reported for their PTP1B inhibitory activity in recent years. This article mainly overviews recent progress in understanding the mechanism of action of PTP1B and food-derived natural PTP1B inhibitors, which will hopefully provide a theoretical rationale for further research on PTP1B inhibitors and the development of new PTP1B inhibitors or hypoglycemic functional foods.

Key words: food-derived; natural compounds; type 2 diabetes; protein tyrosine phosphatase 1B inhibitor

CLC Number:

TS201.4

BAO Meili, WANG Zhenyu. Functional Significance and Structure-Activity Relationship of Food-Derived Protein Tyrosine Phosphatase 1B Inhibitors[J]. FOOD SCIENCE, 2023, 44(17): 258-277.

[1]	. Effect of piperine on circadian rhythm of lipid metabolism-associated genes in obese rats based on lipidomics analysis [J]. FOOD SCIENCE, 0, (): 0-0.
[2]	Qian ZHANG Qi-Ming WANG JIan Ming. Bigels in Food Field: From Their Composition to Their Applications [J]. FOOD SCIENCE, 0, (): 0-0.
[3]	Yan Zhang. Flammulina velutipes polysaccharides alleviates vascular inflammation in mice exposed to benzo[a]pyrene via regulating generation of myeloid cells [J]. FOOD SCIENCE, 0, (): 0-0.
[4]	Yu-Ting WANG Hong Lei. Protective Effect of Auricularia Auricula Melanin on Iron Deficiency Anemia Induced Ulcerative Colitis in Mice [J]. FOOD SCIENCE, 0, (): 0-0.
[5]	LIU Hongxu, SONG Guoku, WANG Zhen, XIA Xiaodong, QIN Ningbo. Anti-inflammatory Mechanism of Coregonus peled Oil via the Inhibition of Nuclear Factor Kappa-B (NF-κB), Signal Transducer and Activator of Transcription 1 (STAT1), and Succinate/Hypoxia-Inducible Factor-1α (HIF-1α) Signaling Pathways [J]. FOOD SCIENCE, 2023, 44(17): 67-78.
[6]	YIN Yanyan, ZHAO Yi, CHU Huicheng, LIANG Jinjie, HAN Xiaojia, CHEN Zujun, WANG Lingzhi. Protective Effect of Coix Seed Bioactive Peptide on Human Umbilical Vein Endothelial Cells Injured by High Glucose [J]. FOOD SCIENCE, 2023, 44(17): 79-85.
[7]	XU Qing, TAN Shuming, YU Lu, YUAN Meng, TAN Yunyun, ZHANG Liqun. Effect and Mechanism of Rosa roxburghii Fruit Polyphenols on Hypertension Induced by NG-Nitro-L-Arginine Methyl Ester in Mice [J]. FOOD SCIENCE, 2023, 44(17): 94-100.
[8]	YAN Xiafeng, HOU Zhaoqin, ZHANG Cuifen, MA Yanfei, WANG Jianjun. Hawthorn Polyphenols Relieve Benzo(a)pyrene-Induced Inflammatory Injury in Respiratory Epithelial Cells [J]. FOOD SCIENCE, 2023, 44(17): 101-109.
[9]	WANG Yuting, WANG Miao, LI Yuanjing, SHI Shuliang, LEI Hong, FENG Lei. Protective Effect of Auricularia auricula Melanin on Iron Deficiency Anemia Induced Ulcerative Colitis in Mice [J]. FOOD SCIENCE, 2023, 44(17): 110-117.
[10]	LI Hanqi, WANG Zhijun, ZHENG Qingyao, CAO Wenhong, CHEN Zhongqin, LIN Haisheng, GAO Jialong, ZHENG Huina. Research Progress on Food-Derived Antithrombotic Peptides [J]. FOOD SCIENCE, 2023, 44(17): 268-285.
[11]	Mei-Li BAO. Functional significance and structure-activity relationship of food-derived PTP1B inhibitors [J]. FOOD SCIENCE, 0, (): 0-0.
[12]	Zhen Wang Ningbo Qin. Anti-inflammatory mechanism of fish oil from Coregonus Peled via the inhibition of NF- κB, STAT1, and Succinate/HIF-1α signaling pathways [J]. FOOD SCIENCE, 0, (): 0-0.
[13]	. Research progress of food derived antithrombotic peptides [J]. FOOD SCIENCE, 0, (): 0-0.
[14]	. Construction of Curcumin Nanoparticles and Cell Uptake in Vitro [J]. FOOD SCIENCE, 0, (): 0-0.
[15]	YANG Dan, YUAN Ying, YAO Xiaolin, QIN Dan, LIU Dechun. Preparation and in Vitro Cell Uptake of Curcumin Nanoparticles [J]. FOOD SCIENCE, 2023, 44(16): 42-49.

Functional Significance and Structure-Activity Relationship of Food-Derived Protein Tyrosine Phosphatase 1B Inhibitors

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments