Dose-Response Modeling of Aflatoxin B1-Induced Apoptosis Rate in Rat Hepatocytes

doi:10.7506/spkx1002-6630-20230328-273

FOOD SCIENCE ›› 2024, Vol. 45 ›› Issue (3): 61-67.doi: 10.7506/spkx1002-6630-20230328-273

• Nutrition & Hygiene • Previous Articles Next Articles

Dose-Response Modeling of Aflatoxin B1-Induced Apoptosis Rate in Rat Hepatocytes

HUANG Aodi, YAN Jiahui, ZHANG Zhaohuan, LIU Haiquan, ZHAO Yong, OU Jie

(1. College of Food Science & Technology, Shanghai Ocean University, Shanghai 201306, China;2. Shanghai Engineering Research Center of Aquatic Product Processing & Preservation, Shanghai 201306, China; 3. Laboratory of Quality & Safety Risk Assessment for Aquatic Products on Storage and Preservation (Shanghai), Ministry of Agriculture and Rural Affairs, Shanghai 201306, China)

Online:2024-02-15 Published:2024-03-06

Abstract

Abstract: This study aimed to construct a dose-response model of aflatoxin B1 (AFB1)-induced apoptosis rate in rat hepatocytes by using quantitative data. The coefficients of determination (R2) and further mathematical tests showed that the Gamma model (R2 = 0.996 4, Akaike information criterion = 37.40, and Bayesian information criterion = 17.19) was superior to other models. Hence, the Gamma model was recommended as the optimal dose-response model for apoptosis rate in rat hepatocytes after acute exposure to AFB1 for hazard characterization in the framework of AFB1 risk assessment.

Key words: aflatoxin B1; hepatocyte apoptosis; risk assessment; dose-response model

CLC Number:

TS201.6

HUANG Aodi, YAN Jiahui, ZHANG Zhaohuan, LIU Haiquan, ZHAO Yong, OU Jie. Dose-Response Modeling of Aflatoxin B1-Induced Apoptosis Rate in Rat Hepatocytes[J]. FOOD SCIENCE, 2024, 45(3): 61-67.

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Dose-Response Modeling of Aflatoxin B1-Induced Apoptosis Rate in Rat Hepatocytes

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