Abstract: In this paper ethyl acetoacetate and ethanediol as raw materials synthesized fructone. By a single factor synthesis and an orthogonal test, with the synthesis of fructone as study targets, the ettects of catalysts,materials ratio, temperature, time, heating ways and so on were studied. With microwave irradiation and phase transfer catalysis, the optimum reaction conditions were as follows: NaHSO4/FeCl3 as catalyst, PEG-800 as phase transfer catalyt, ethyl acetoacetate : ethanediol as 1∶1.5～1.8 (mol), methylbenzene as solvent and microwave irradiation time in 8～12 min. The yield was up to 91.5%. The synthesis product was characterized by refraction index, chemical and physical property, IR, GC, MS and 1HNMR spectra.

Key words: Microwave irradiation , Phase transfer catalysis, Synthesis , Perfume, Fructone