Abstract: The supercritical fluid extraction technology of Propolis flavonoids was optimized by single-factor and orthogonalexperiments. Experimental results showed that the successive order of different effect factors on extraction rate was extrac-tion pressure>alcohol concentration>solid-liquid ratio>extraction temperature. The optimal experimental parameters were25MPa extraction pressure, 95% alcohol concentration, 6:1 solid-liquid ratio, 50℃ extraction temperature, 4h extraction timeand 35kg/h fluid velocity. The results also showed that the extraction rate of flavonoids was considerable large, and theextraction product was pure, golden in color and high in purity.

Key words: Supercritical CO2 , Extraction , Modifier , Propolis , Flavonoids