Abstract: Objective To study the protective effects of flavonoids of ginkgo biloba on chronic alcohol induced oxidative damageon rat. Methods The rat was treated by gastric incubation with alcohol. After administered with preventive medicine flavonoidsof ginkgo biloba, the activity of ALT(Glutamic-Pyruvic Transaminase, ALT)、AST(Glutamic Oxaloacetic Transaminase, AST)were measured in rat serum, meanwhile, the concentration of ROS(Reactive Oxygen Species)、 Glutathione (GSH)、Malondialdehyde (MDA) on the 30th day and 60th day of the experiment, respectively were determined to indicate serumoxidative-damage. Result The preventive experiment display that on the 30th day, the low and high doses flavonoid of ginkgobiloba can significantly decrease the high ROS、ALT、AST and MDA levels induced by alcohol (p<0.01);moreover, the highdose can increase GSH level reduced by alcohol markedly(p<0.01) on the 60th day. Conclusion flavonoids of ginkgo biloba havesome protective effects on chronic alcohol induced oxidative damage on rat serum.

Key words: flavonoid of ginkgo biloba, chronic alcohol intakes, oxidative injury