Preparatory Study :Effect of LSPC on the Tyrosinase Activity and the Melanin Biosynthesis of Melanin and the Tyrosinase Activity

Abstract

Abstract: Objective: To discuss the inhibiting mechanism of LSPC on the biosynthesis. Methods: Tyrosinase inhibiting rate isdetermined and Lineweaver-Burk curve is made by determining the tyrosinase activity before and after drug(LSPC) interfer-ence oxidaut of method, on which we deduce the inhibiting types of LSPC.Results: LSPC can inhibit the tyrosinase activityremarkably with the half inhibiting concentration IC50 1.155g/L, and can effectively inhibit the transition from dopa, the medial-production when melanin is formed , to melanin with the half inhibiting concentration IC50 1.750g/L.Conclusion: LSPC can inhibitthe tyrosinase activity and it is the competitive inhibitor of tyrosinase.

Key words: lotus seedpod, procyanidins, L-Dopa

DUAN Yu-Qing, LIU Rui, XIE Bi-Jun. Preparatory Study :Effect of LSPC on the Tyrosinase Activity and the Melanin Biosynthesis of Melanin and the Tyrosinase Activity[J]. FOOD SCIENCE, 2004, 25(3): 169-174.

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Preparatory Study :Effect of LSPC on the Tyrosinase Activity and the Melanin Biosynthesis of Melanin and the Tyrosinase Activity

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