Abstract: In the present paper, the hypoglycemic effect of fruit of Nitraria tangutorum Bobr. was studied from Qinghai TsaidamBasin. The blood glucose levels in each animal group were determined after oral administration, examined with the diabetesmodels of Wister rat and Kunming strain mouse induced by alloxan, the hyperglycemic models of Kunming strain mouseinduced by epinephrine and glucose, and the control animals. Further, the acute toxicity experiment was made. It showed thatthe fruit of Nitraria tangutorum Bobr. at the dose of 1.8g/kg and 3.6g/kg not only had better therapeutical action on the diabetesmodel of Kunming strain mouse induced by alloxan, but also made an increase in the glucose-toleration of Wister rat in thediabetes model induced by alloxan. It had also significant hypoglycemic function on hyperglycemic animal models induced byepinephrine and glucose. However, it had no effect on the blood glucose level in the control animals. The acute toxicityexperiment showed the maximum oral dosage was 53.5g/kg. The Result showed that the fruit of Nitraria tangutorum Bobr. hasbetter hypoglycemic effect on various hyperglycemic animal models.

Key words: fruit of Nitraria tangutorum Bobr., hypoglycemic effect, animal experiment, glucose-toleration