Abstract: Objective: To study the effect of Ampelsis grossedentata on lowering plasma lipids level. Methods: The hyperlipemia rats were fed with Ampelsis grossedentata on three different dosages respectively everyday. After 30d, the levels of TC,TG and HDL-C were assayed.100 patients with primary hyperlipidemia were randomly allocated into two groups, one treated group and the other control group. Patients in the treated group were given 9g/d of Ampelsis grossedentata. After 45d, the level of TC,TG and HDL-C were assayed. Results: the TC and TG level of rats could be lowered, the HDL-C level of rats could be increased. Whereas the effective rate of the patients treated group on reducing levels of TC, TG and plasma lipids were respectively 42%, 72% and 28%.Conclusion: In the study, Ampelsis grossedentata could lower the plasma lipids level.

Key words: Ampelsis grossedentata, antilipemic, hyperlipidemia, total flavonoids, dihydromyricetin