Abstract: Objective: To study the toxicity of Mogrosides. Methods: Acute toxicity experiments with mice. Ames test with Salmonella typhosa (TA97, TA98, TA100, TA102), and four weeks toxicity experiment with dogs were administrated according to documents. Results: The LD50 of Mogrosides by i.g. to mice was large than 10000mg/kg .It was actual no toxicity. The Ames result of Mogrosides was also negative .The dogs were given (i.g.) Mogrosides 3.0g/kg for four weeks and the detection and examination results showed that there were no changes in dog’s blood constituents, liver function and kidneys.The dog’s blood and urine sugar level were normal. Mogrosides also made no morphologic changes to heart, liver, kidneys, lungs, and spleen in dogs. Conclusion: Mogrosides was one kind of components without toxicity.

Key words: momordica grosueri swingle, mogrosides, toxicity