Abstract: Antimicrobial peptides have been discovered from tissues and organisms representing virtually every kingdom and phylum, ranging from prokaryotes to humans. Generally antimicrobial peptides have the broad spectrum antibacterial activity, its antibacterial mechanism became the domestic and foreign research hot spot in recent years. This article summarized the newest progress whicht hea ntibacterial peptide andi ts antibacterialm echanisms tudies, elaboratedt hev italr oleo ft he innatei mmunity when the antibacterial peptide, which separated from mammal, display antibacterial activity, and has carried on the forecast to thea ntibacterialp eptided evelopment applicationp rospect.

Key words: antibacterial peptide, antibacterial mechanism, review, prospect