Synthesis and Antibacterial Activity of Trans-but-2-enedioic Acid Bis-aromatic Alcohol Ester

Abstract

Abstract: A series of trans-but-2-enedioic acid bis-aromatic alcohol ester have been firstly synthesized by direct reaction of trans-but-2-enedioic acid with aromatic alcohol. The products were characterized with 1H NMR and FTIR. All the characterization data are consistent with the theoretic compositions and structures. The antibacterial activities against Bacillus subitilis,Mycococcus tetragenus Krasil’ nikov,Staphylococcus aureus and Escherichia coli were tested by the method of phototurbidometry. All of the derivatives showed strong antibacterial activity against bacteria tested. The antibacterial activities of the derivatives were more effective with longer chain of the aromatic alcohol and halogenated with halide. It showed that the derivatives are potent and promising antibacterial agents.

Key words: trans-but-2-enedioic acid bis-aromatic alcohol ester, synthesis, antibacterial activity

欧Guang-南 , Zhou-Chang-Yi, Gao-Fang, 蓝Huang-Long, Liu-Xiao-Yu, Lin-Cheng, Weng-Shi-Yu, Qiu-Jie, Cai-Lian-Qiao. Synthesis and Antibacterial Activity of Trans-but-2-enedioic Acid Bis-aromatic Alcohol Ester[J]. FOOD SCIENCE, 2006, 27(11): 207-209.

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Synthesis and Antibacterial Activity of Trans-but-2-enedioic Acid Bis-aromatic Alcohol Ester

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