Effect of Methionine Chelate Iron on the Liver Gene Expression and Metabolism of Rat

Abstract

Abstract: Using Affymetrix genechip to analyse the differential gene expression in rats which fed with ferrous methionine chelate and ferrous sulfate respectivly. To found a model of anaemic rat which dietary were iron deprivation for 15 days, then 20 SD rats were divided randomly into two groups. The rats were fed with same iron level (Fe 35mg/kg) of ferrous methionine chelate and ferrous sulfate respectively. After 4th and 7th day of iron supplementation, rats gain, the contents of hemoglobin (Hb) and serum total iron-binding capacity of rats were measured. Gene expression of liver were detected by highdensity oligonuleotide array and compared ferrous methionine chelate group with ferrous sulfate group at the 7th day. The body gains, contents of hemoglobin (Hb) and serum total iron-binding capacity of rats fed with ferrous methionine chelate were higher than ferrous sulfate group. Ferrous methionine chelate induced upregulated expressed genes involved globin (Hbg1), ferric transfer protein (FTL1), en-zymes of cholesterol synthesize, fatty acid synthesize and ATP synthesase in liver. These findings may thus explain different functions between ferrous methionine chelate and ferrous sulfate.

Key words: rat, ferrous methionine chelate, differential genes expression, microarray

WANG Li-kuan1,2,LE Guo-wei1,2,GU Bo2,LI Liang2,SHI Yong-hui. Effect of Methionine Chelate Iron on the Liver Gene Expression and Metabolism of Rat[J]. FOOD SCIENCE, 2006, 27(12): 735-739.

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Effect of Methionine Chelate Iron on the Liver Gene Expression and Metabolism of Rat

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