Abstract: This paper studied the effects of anthocyanin-rich extract from black rice on advanced plaques in ApoE deficientmice. ApoE deficient mice of 30 weeks of age were randomly divided into 3 groups: mice in two experimental groups were fedchow diets supplemented with black rice anthocyanin-rich extract and simvastatin seperately, while control group was fed anormal chow diet. Lipid profile of serum, plaque area and matrix metalloproteinase content in the innominate artery were assayed.Results showed that the anthocyanin-rich extract lowers TC, TG and LDL-C levels in serum, and decreases plaque area andMMP content in the innominate artery of mice. Conclusion: anthocyanin-rich extract can inhibit further development of advancedplaque in ApoE deficient mice.

Key words: atherosclerosis, plaque, black rice, anthocyanin