Abstract: In this paper, it was studied that the ultrasonic extraction method was one of ideal methods by comparing different methods of extracting the total Jujuboside from Ziziphus jujuba Mill and the optimum conditions were obtained by orthogonal test. The Ziziphas jujuba Mill extracted solution was given to the mice according to different doses and, to induce sleep afterwards. The sleeping latency time and sleeping time were assayed. The results proved that the Jujuboside from Ziziphus jujuba Mill product significantly improves the sleep quality of mice and the optimal low dose is obtained.

Key words: jujuboside, ultrasonic extraction, dormancy improving