FOOD SCIENCE ›› 2006, Vol. 27 ›› Issue (9): 247-249.

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Study on Effects of EGCG on Experimental Focal Brain Ischemia Injury in Rats

   Cai-Fei,   Li-Cai-Rong,   Wu-Ji-Liang,   Chen-Jin-He   

  1. 1.Division of Pharmacology, School of Pharmacy, Xianning College, Xianning 437100, China; 2.Division of Pathology, Xianning College, Xianning 437100, China;3.Department of Pharmacology, College of Medical, Wuhan University, Wuhan 430071, China;4.Department of Pharymacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
  • Online:2006-09-15 Published:2011-10-20

Abstract: Objective: To study the protective effects and mechanism of EGCG (Epigallocatechin-3-gallate) on focal brain ischemia injury in rats. Methods: The ischemia model was created by right middle cerebral artery occlusion(MCAO). Rats were randomly divided into five groups. The EGCG groups were treated by EGCG 30min before MCAO. The sizes of cerebral infarction were measured after 6h of MCAO. The content of Ca2+ and excitatory amino acids in brain tissue were also determined. Results: The sizes of cerebral infarction of EGCG groups are less than that of the ischemia group. The contents of Ca2+ and excitatory amino acids of EGCG groups decrease more significantly than those of the ischemia group. Conclusion: EGCG may have the protective effects on focal brain ischemia injury in rats through reducing the content of Ca2+ and excitatory amino acids in brain tissue.

Key words:  , EGCG(Epigallocatechin-3-gallate); MCAO(middle cerebral artery occlusion); excitatory amino acids;