Effects of Lactic Acid on Production of Pro-and Anti-inflammatory Cytokines

Abstract

Abstract: Objective: To explore and evaluate the effects of lactic acid on the production level of IL-6, IFN-γ, IL-1β, TNF-α, IL-10 and IL-4 in sera of mice and the regulative effect of lactic acid on immune system. Methods: By ELISA assay the contents of IL-6, IFN-γ, IL-1β, TNF-α, IL-10 and IL-4 were examined in sera of mice after orally administration, intraperitoneal injection, intravenous injection of lactic acid to mice. Sera was separated after lactic acid was given 4, 3 and 3h. Results: It showed that the content of IL-6, IFN-γ, TNF-α, IL-10, IL-4 were more significantly increased than the control groups after orally administration, intraperitoneal injection, intravenous injection of lactic acid to mice and the content of IL-1β was more significantly decreased than control groups. Conclusion: All of the three approaches, the effect of intraperitoneal injection is the most obvious. Lactic acid is the metabolic product of Lactobacillus. The immunomolating function of Lactobacillus zymolytic food can be exerted by lactic acid, which through the cytokine secreted by immunocyte in gut mucosal system.

Key words: lactic acid, cytokine

YU Li-Qin, PANG Guang-Chang, DAI Yi. Effects of Lactic Acid on Production of Pro-and Anti-inflammatory Cytokines[J]. FOOD SCIENCE, 2007, 28(12): 439-442.

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Effects of Lactic Acid on Production of Pro-and Anti-inflammatory Cytokines

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