Preparation of Lycopene Liposomes

Abstract

Abstract: Objective:To prepare lycopene liposomes.Methods:Lycopene liposomes were prepared by conventional rotary- evaporated film-ultrasonication method The uniform design coupled with computerized optimization was adopted to screen the formulations and preparation processes,lycopene of liposome was detected by high performance liquid chromatography (HPLC).Differential scanning calorimetry(DSC)thennograms of the liposomal samples were recorded respectively.Results: The data showed that the ratio of lycopene,cholesterol and phospholipids is 3:10:100.The optimum concentration of PBS (phosphate buffer solution)is 0.01mol/L and the temperature of PBS is 31℃.Conclusion:The liposomes are uniform and unilamellar particle with effective diameter of 0.7μm and the optimum entrapment efficiency is 68%.

Key words: lycopene, liposomes, uniform design, differential scanning calorimetry

TIAN Yan-Yan, DUAN Xiang-Lin, CHANG Yan-Zhong. Preparation of Lycopene Liposomes[J]. FOOD SCIENCE, 2007, 28(4): 128-132.

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Preparation of Lycopene Liposomes

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